Table 2.
Effects of autophagy-related miRNAs on cancer radiotherapy
| Effect on autophagy | Name | Dysregulated | Autophagy-related target | Effect on radiotherapy | Tested cell line (tissue origin) | Ref. |
|---|---|---|---|---|---|---|
| Inhibition | miR-17-5p | up-regulated | Beclin 1 | radiosensitivity | U87 (glioblastoma) | 59 |
| miR-21 | up-regulated | PTEN | radiosensitivity | Hela, Siha(cervical cancer) | 168 | |
| miR-23b | downregulated | ATG12 | radiosensitivity | BxPC3, PANC-1 (pancreatic cancer) | 139 | |
| miR-31 | downregulated | Beclin 1, ATG, DRAM | radiosensitivity | Primary cultured cells (colorectal cancer) | 169 | |
| miR-93 | up-regulated | Beclin 1, ATG5, ATG4B, SQSTM1 | radiosensitivity | U87 (glioblastoma) | 170 | |
| miR-101 | downregulated | STMN1 | radioresistance | CNE-2, 5-8F (nasopharyngeal carcinoma) | 171 | |
| miR-129-5p | downregulated | HMGB1 | radiosensitivity | MCF-7, MDA-MB-231 , BT549, BT474 (breast cancer) | 43 | |
| miR-183-5p | up-regulated | ATG5 | radiosensitivity | Caco-2 (colon cancer) | 172 | |
| miR-200c | downregulated | UBQLN1 | radiosensitivity | MDA-MB-231, BT549 (breast cacer) | 173 | |
| miR-214 | downregulated | ATG12 | radiosensitivity | SW480, HCT116 (colorectal cancer) | 174 | |
| miR-216b | up-regulated | Beclin 1 | radioresistance | PANC-1 (pancreatic cancer) | 175 | |
| miR-450a-5p | downregulated | DUSP10 | radioresistance | ECA (esophageal cancer) | 176 | |
| Activation | miR-138-5p | downregulated | EIF4EBP1 | radiosensitivity | HONE1, HK1 (nasopharyngeal carcinoma) | 141 |
| miR-301a/b | up-regulated | NDRG2 | radioresistance | LNCaP (prostate cancer) | 142 | |
| miR-1246 | up-regulated | mTOR | radioresistance | A549, PC9 (lung cancer) | 177 | |
| miR-4673 | up-regulated | CDK-18 | radioresistance | SKBR3 (breast cancer) | 178 |