Figure 4.

LncRNA Regulates HCC Invasion and Progression by Modulating Tumor Immune Escape. LncRNA promotes tumor immune escape in HCC. For example, NEAT1 inhibits the expression of miR-155 and increases the activity of Tim3, resulting in apoptosis of CD8⁺ T cells. Lnc-Tim3 inhibits NF-AT1 and AP1 signaling, thereby inducing CD8⁺ T cell failure. In addition, lnc-EGFR activates the RAS/ERK/AP1/NF-AT1 signaling pathway to promote Treg cell differentiation, thereby contributing to tumor cell immune escape.