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. 2021 Jan 1;17(1):204–219. doi: 10.7150/ijbs.51362

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Pattern of mechanisms of IL-6 promoting the integrity of the intestinal epithelium. IL-6 assists maintain intestinal homeostasis through both classical and cross-signaling pathway. This is the enlarged view of the role IL-6 plays in the intestinal epithelium. IL-6 promotes the proliferation of paneth cells in the crypt through (JAK/STAT3 classic signaling). This preserves the intestinal integrity by inducing gene transcription via trans-signaling (sIL-6R: soluble IL-6 receptor; ZO: zonula occludins).