Table 1.

Key factors in IL-6 related gastrointestinal tumor

Natural inhibitors	Inflammation initiators	Synthetical inhibitors
Ly6/Plaur domain-containing 8 (LYPD8) 134	Monocarboxylate transporter 4 (MCT4) 135	Tocilizumab (TCZ) 136
6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (M1) 137	Glucagon-like peptide-1 (GLP-1) 138 Glucose‑dependent insulinotropic polypeptide (GIP) incretins 138	Silibinin 139 [herbal]
	Corticotrophin-releasing hormone (CRH)/CRHR1 140	KIOM-MA/MA128 141 [herbal]
	Toll‐like receptor 4 142	Cocoa 143
	Sonic hedgehog (SHH) signaling 144	IL-6 monoclonal antibody (mAb) 145
		Probiotic agent VSL#3 146; Balsalazide (BSZ) 146