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. 2021 Jan 1;17(1):353–367. doi: 10.7150/ijbs.51309

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Fig 7 — The effect of E-cadherin knockdown on mechanically stretched skin. (A) Significantly thicker skin tissue was observed in the siEcad+HKP group; 60% (3/5) of the siControl group developed complications (e.g., flap necrosis); the siEcad+HKP group developed no complications. (B) Masson trichrome staining showing more intact flap structure, increased collagen production, and better organized ECM in the siEcad+HKP group compared to the siControl group. Scale bar: 100 mm. N = 3-5 rats over three experiments. (C) Dried skin thickness (formalin dehydration) demonstrating that the siEcad+HKP group had significantly thicker skin than that the siControl group. *P < 0.05. N = 3 rats/group repeated 3-5 experiments. (D) ultrasound determined skin thickness of siEcad on day 14. The siEcad+Accell group showed significantly increased flap thickness compared with the siControl group. N = 3 rats/group repeat 3-5 experiments. (E) Ultrasound images of the siEcad+HKP group and siControl group on day 14. The siEcad+HKP group showed increased flap thickness compared with the siControl group.