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miR-340 is associated with various genes modulating cancer cell proliferation. Upregulated miR-340 inhibits the expression of JAK1, SKP2, and CDK4, repressing cell proliferation, while it inhibits the expression of BMP4 and cyclin G2, inducing cell proliferation. miR-340 inhibits the Wnt/β-catenin signaling pathway by targeting LGR5 or FHL2, as well as the CTNNB1-mediated Notch signaling pathway, resulting in repressed cell proliferation.
