Table 1.
miR-340 Dysregulates in Various Cancers and Their Target Genes
| Cancer Type | Target gene | Reference |
|---|---|---|
| miR-340 Downregulation | ||
| BC | LGR5 | 56 |
| BC | —— | 7, 103 |
| BC | ZEB1 | 29 |
| BC | CTNNB1, c-MYC | 71 |
| BC | c-Met | 70 |
| CRC | ANXA3 | 99 |
| CRC | RLIP76 | 50 |
| CRC | —— | 78 |
| Gallbladder carcinoma | NT5E | 79 |
| GBM | —— | 91, 92, 104 |
| GBM | NRAS | 95 |
| GBM | CDK6, cyclin-D1, cyclin-D2 | 42 |
| GBM | Bcl-w, Sox2 | 53 |
| GBM | ROCK1 | 52 |
| GC | SPP1 | 59 |
| GC | —— | 18 |
| HCC | DcR3 | 112 |
| HCC | SKP2 | 47 |
| HCC | JAK1 | 48 |
| HCC | Nrf2 | 87 |
| Laryngeal squamous cell carcinoma | EZH2 | 46 |
| Melanoma | —— | 34, 113 |
| NSCLC | ZNF503 | 114 |
| NSCLC | CDK4 | 40 |
| NSCLC | SKP2 | 44 |
| OC | FHL2 | 20 |
| OC | BAG3 | 67 |
| OC | NF-κB1 | 66 |
| OS | STAT3 | 115 |
| OS | LPAATβ | 86 |
| OS | ROCK1 | 77, 101 |
| Oral Squamous Cell Carcinoma | Glut1 | 116 |
| Pancreatic cancer | BICD2 | 117 |
| PCa | MDM2 | 57 |
| Triple-negative breast cancer | —— | 118 |
| miR-340 Upregulation | ||
| GC | SOCS3 | 19 |
| GC | cyclin G2 | 41 |
| GC | —— | 93, 107 |
| Thyroid cancer | BMP4 | 58 |
BC: breast cancer; CRC: colorectal cancer; GBM: glioblastoma multiforme; GC: gastric cancer; HCC: hepatocellular carcinoma; NSCLC: non-small cell lung cancer; OC: ovarian cancer; OS: osteosarcoma; PCa: Prostate cancer.