Table 3.

Univariate and multivariate Cox regression analysis of RFS in 467 TCGA ccRCC patients

	Univariate analysis				Multivariate analysis
Parameters	P	HR	95%CI		P	HR	95%CI
			Lower	Upper			Lower	Upper
Tumor stage
T1/T2 (66.2%)		1.0000				1.0000
T3/T4 (33.8%)	<0.0001	4.5180	3.0690	6.6510	0.4445	0.7727	0.3989	1.4966
Metastasis
M0 (88.7%)		1.0000				1.0000
M1 (11.3%)	<0.0001	12.0300	8.0760	17.9100	<0.0001	5.2895	3.2799	8.5303
Pathological stage
I/II (63.2%)		1.0000				1.0000
III/IV (36.8%)	<0.0001	6.8300	4.4650	10.4500	0.0006	4.0809	1.8324	9.0887
Histological grade
Grade 1/2 (46.9%)		1.0000				1.0000
Grade 3/4 (53.1%)	<0.0001	3.3350	2.1480	5.1760	0.0418	1.6327	1.0183	2.6177
ACE2	<0.0001	0.8075	0.7485	0.8712	<0.0001	0.8023	0.7375	0.8729