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. 2020 Dec 9;11:573550. doi: 10.3389/fimmu.2020.573550

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Copyright © 2020 Kiyan, Tkachuk, Rong, Gorrasi, Ragno, Dumler, Haller and Shushakova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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uPAR is essential for the response of kidney proximal tubular epithelial cells to LPS. (A, B) LPS- induced expression of IL-6 and IL-8 by human renal proximal tubule epithelial cell (HK-2) was assessed by TaqMan RT-PCR (A) and ELISA (B). (C) HMGB1-dependent IL-6 and IL-8 expression by HK-2 cells was assessed by TaqMan RT-PCR. (D) Human renal epithelial HK-2 cells were lentivirus-infected to express Gaussia luciferase under control of NFκB and GAPDH promoters. Enzyme activity was measured in cell conditioned media 10 h after stimulation with LPS. Data are presented as mean ± SD from three independent experiments, *P < 0.05; **P < 0.01; **P < 0.001.