Figure 7.

Bcr-Abl kinase activity reversely inhibits Blnk and Foxo1 expression in BCR-ABL1-transformed pro-B cells. The (A) mRNA and (B) protein levels of BLNK and FOXO1 gene in BCR-ABL1-transformed, imatinib-treated (0, 6 and 9 µM for 24 h) pro-B cells. Gene mRNA fold expression values have been normalized to the GAPDH; the protein levels were quantified by the ImageJ program and normalized to actin. Data are representative of three independent experiments. Error bars represent the mean ± SEM. *P<0.05 and **P<0.01. Blnk, B-cell linker; Foxo1, forkhead box proteinO1.