Figure 5.

Polyphyllin VII inhibits tumor growth in vivo. SKOV3 cells were subcutaneously implanted into nude mice. Each treatment group consisted of three mice treated with polyphyllin VII (1 mg/kg body weight) for 31 days. (A) Tumor growth curves were constructed based on tumor size, which was measured every 2 days for each treatment condition. (B) Wet weights of tumors were determined at autopsy. Columns represent mean of three tumors. *P<0.05 compared with the control group; **P<0.01 compared with control group. (C) Representative image of tumor from each group. (D and E) Western blot analysis of c-caspase-3, BCL-2, and BAX expression after treatments.