Figure 2:

Differentially methylated regions (DMRs) associated with first-trimester urinary BPA exposure. Three DMRS in cord blood leukocytes in (a) HOXA-AS3, (b) PRSS22, and (c) ZSCAN12P1 were identified via DMRcate that were associated with first-trimester BPA levels (modeled as a continuous variable and adjusted for infant sex, batch, and estimated nRBCs and B cells). Here, proportion of DNA methylation (beta values) at CpG sites within the DMR are displayed, averaged across quartiles of BPA. Quartile cutoffs are as follows: Q1 [<LOD, 0.348], Q2 [0.349, 0.897], Q3 [0.898, 1.90], and Q4 [1.91, 6.76] in nanograms per milliliters BPA.