Table 2:
Differentially methylated CpG sites associated with maternal first-trimester urinary BPA exposure
| Locus | Gene name | Relation to CpG island | Effect estimate using beta-values | q-value |
|---|---|---|---|---|
| chr1: 43437674 | SLC2A1-AS1 | Open sea | −0.10 | 0.00069 |
| chr1: 14591868 | Open sea | −0.060 | 0.00154 | |
| chr1: 200992656 | KIF21B | Island | 0.027 | 0.00154 |
| chr19: 36661673 | Open sea | 0.031 | 0.00155 | |
| chr13: 21049223 | CRYL1 | Open sea | −0.063 | 0.00166 |
| chr18: 33160855 | North Shore | −0.0071 | 0.00239 | |
| chr3: 122512541 | HSPBAP1 | Island | 0.028 | 0.00239 |
| chr8: 10622805 | Open sea | −0.027 | 0.00290 | |
| chr2: 216237359 | FN1 | Open sea | −0.057 | 0.00290 |
| chr16: 51184562 | SALL1 | Island | −0.00096 | 0.00290 |
| chr20: 10199434 | SNAP25 | North Shore | −0.0011 | 0.00290 |
| chr15: 85660361 | PDE8A | Open sea | −0.060 | 0.00290 |
| chr8: 72756155 | MSC | Island | −0.00077 | 0.00333 |
| chr12: 121698404 | CAMKK2 | Open sea | −0.058 | 0.00333 |
| chr19: 3180815 | South Shore | −0.00096 | 0.00333 | |
| chr2: 85822726 | RNF181 | Island | −0.0038 | 0.00370 |
| chr2: 239039182 | ESPNL | North Shore | −0.045 | 0.00402 |
| chr8: 33342681 | MAK16 | Island | −0.00086 | 0.00402 |
| chr7: 142536625 | Open sea | −0.049 | 0.00402 | |
| chr11: 26595206 | MUC15 | Open sea | −0.060 | 0.00487 |
| chr2: 71017846 | FIGLA | Island | −0.017 | 0.00712 |
| chr7: 1068244 | C7orf50 | Island | 0.013 | 0.00712 |
| chr5: 106879524 | EFNA5 | Open sea | −0.030 | 0.00753 |
| chr2: 172957268 | North Shore | −0.015 | 0.00913 | |
| chr12: 11324011 | SMIM10L1 | Island | −0.00060 | 0.00963 |
| chr3: 46752152 | TMIE | Open sea | −0.037 | 0.01499 |
| chr16: 8735575 | METTL22 | Open sea | −0.028 | 0.01543 |
| chr12: 62653559 | USP15 | North Shore | −0.0021 | 0.01769 |
| chr3: 56502021 | ERC2 | Island | −0.012 | 0.01797 |
| chr1: 111098247 | Island | −0.00062 | 0.01906 | |
| chr12: 123380878 | VPS37B | Island | −0.0083 | 0.02749 |
| chr19: 2462065 | Island | −0.00094 | 0.02749 | |
| chr10: 636076 | DIP2C | Open sea | −0.027 | 0.02775 |
| chr14: 62210927 | HIF1A | Open sea | −0.017 | 0.03846 |
| chr4: 154400013 | KIAA0922 | Open sea | −0.031 | 0.03846 |
| chr4: 154349775 | Open sea | −0.015 | 0.03846 | |
| chr12: 1058965 | RAD52 | Island | 0.011 | 0.03990 |
| chr8: 11059042 | XKR6 | Island | −0.00049 | 0.04156 |
Note: Results shown are for CpG sites associated with maternal urinary first-trimester BPA exposure below false discovery rate (FDR) significance of q < 0.05. Model was adjusted for infant sex, nRBCs, Bcells, and sample plate (batch). Effect estimate is the unit change with each 1 ng/ml increase in BPA from the model of M-values (logit-transformed beta values). Beta is the effect estimate when modeling the proportion of methylation (beta value) at the same CpG site instead and represents the increase in proportion methylated per each nanograms per milliliters increase in first-trimester BPA. The beta estimate is included for interpretation purposes; significance values are generated from the M-value analysis.