Table 3:
Differentially methylated regions in association with maternal first-trimester urinary BPA exposure
| Chromosome | Gene Name | Start (bp) | End (bp) | Number of CpG Sites | P-valuea | Max Beta Change per nanograms per milliliters BPA increaseb |
|---|---|---|---|---|---|---|
| 7 | HOXA-AS3 | 27183794 | 27184375 | 18 | 1.79E−14 | 0.0190 |
| 16 | PRSS22 | 2907517 | 2908715 | 13 | 6.83E−18 | 0.0376 |
| 6 | ZSCAN12P1 | 28058802 | 28059208 | 7 | 2.25E−13 | −0.0388 |
Significance considered at q < 0.05.
a
Minimum FDR P-value for the region.
b
For interpretability, changes across the DMR are reported as proportion methylated (beta), though models used logit-transformed beta values (M-values).