Table 4:
Gene-sets enriched for differentially methylated genes in cord blood leukocytes by maternal first-trimester urinary bisphenol exposures using LRPath.
| Pathway ID | Pathway name | Database with concept | No. of genes in concept | q-value | Direction |
|---|---|---|---|---|---|
| Panel A: pathways associated with maternal first-trimester urinary BPA exposure | |||||
| GO: 0005132 | Type I interferon receptor binding | GOMF | 13 | 7.82E−07 | Up |
| GO: 0000786 | Nucleosome | GOCC | 86 | 1.53E−04 | Up |
| GO: 0044815 | DNA packaging complex | GOCC | 92 | 1.53E−04 | Up |
| GO: 0005549 | Odorant binding | GOMF | 81 | 3.07E−04 | Up |
| GO: 0033139 | Regulation of peptidyl-serine phosphorylation of STAT protein | GOBP | 18 | 0.00206 | Up |
| GO: 0033141 | Positive regulation of peptidyl-serine phosphorylation of STAT protein | GOBP | 17 | 0.00206 | Up |
| GO: 0002323 | Natural killer cell activation involved in immune response | GOBP | 25 | 0.00258 | Up |
| GO: 0042501 | Serine phosphorylation of STAT protein | GOBP | 22 | 0.00258 | Up |
| GO: 1900424 | Regulation of defense response to bacterium | GOBP | 11 | 0.00258 | Up |
| GO: 0002922 | Positive regulation of humoral immune response | GOBP | 15 | 0.00359 | Up |
| GO: 0001055 | RNA polymerase II activity | GOMF | 10 | 0.00570 | Up |
| GO: 0007259 | JAK-STAT cascade | GOBP | 155 | 0.00584 | Up |
| GO: 0042100 | B-cell proliferation | GOBP | 81 | 0.00584 | Up |
| GO: 0043330 | Response to exogenous dsRNA | GOBP | 40 | 0.00584 | Up |
| GO: 0097696 | STAT cascade | GOBP | 155 | 0.00584 | Up |
| GO: 0006959 | Humoral immune response | GOBP | 157 | 0.00631 | Up |
| GO: 0042742 | Defense response to bacterium | GOBP | 205 | 0.00837 | Up |
| GO: 0071880 | Adenylate cyclase-activating adrenergic receptor signaling pathway | GOBP | 18 | 0.00917 | Up |
| hsa04623 | Cytosolic DNA-sensing pathway | KEGG | 51 | 0.00982 | Up |
| GO: 0016290 | Palmitoyl-CoA hydrolase activity | GOMF | 11 | 0.0105 | Up |
| GO: 0007189 | Adenylate cyclase-activating G-protein coupled receptor signaling pathway | GOBP | 82 | 0.0164 | Up |
| GO: 0007192 | Adenylate cyclase-activating serotonin receptor signaling pathway | GOBP | 11 | 0.0164 | Up |
| GO: 0071875 | Adrenergic receptor signaling pathway | GOBP | 25 | 0.0184 | Up |
| GO: 0032993 | Protein-DNA complex | GOCC | 154 | 0.0209 | Up |
| hsa04630 | Jak-STAT signaling pathway | KEGG | 145 | 0.0213 | Up |
| hsa04140 | Regulation of autophagy | KEGG | 30 | 0.0213 | Up |
| GO: 0033617 | Mitochondrial respiratory chain complex IV assembly | GOBP | 13 | 0.0337 | Up |
| GO: 0034340 | Response to type I interferon | GOBP | 79 | 0.0337 | Up |
| GO: 0060337 | Type I interferon signaling pathway | GOBP | 75 | 0.0337 | Up |
| GO: 0071357 | Cellular response to type I interferon | GOBP | 75 | 0.0337 | Up |
| GO: 0097034 | Mitochondrial respiratory chain complex IV biogenesis | GOBP | 13 | 0.0337 | Up |
| hsa05320 | Autoimmune thyroid disease | KEGG | 44 | 0.0341 | Up |
| GO: 0050830 | Defense response to Gram-positive bacterium | GOBP | 65 | 0.0381 | Up |
| hsa05322 | Systemic lupus erythematosus | KEGG | 118 | 0.0403 | Up |
| GO: 0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | GOBP | 183 | 0.0457 | Up |
| GO: 0002286 | T-cell activation involved in immune response | GOBP | 84 | 0.0460 | Up |
| GO: 0019731 | Antibacterial humoral response | GOBP | 35 | 0.0460 | Up |
| GO: 0005665 | DNA-directed RNA polymerase II, core complex | GOCC | 17 | 0.0497 | Up |
| Panel B: pathway associated with maternal first-trimester urinary BPF exposure | |||||
| hsa05322 | Systemic lupus erythematosus | KEGG | 118 | 0.0296 | Up |
Note: Significance was considered at FDR q < 0.05.
‘Concept’ represents gene-sets.
GO, Gene Ontology; MF, molecular function; BP, biological process; CC, cellular component; KEGG databases, Kyoto Encyclopedia of Genes and Genomes databases.