Table 2.
The genotype and allele frequencies of SNPs in the PTC and NC groups
| SNPs | Group | Genotypic association (%) | Allelic association (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1/1 | 1/2 | 2/2 | χ2 | p | 1 | 2 | χ2 | p | ||
| rs12427141 (G>A) | PTC | 481 (71.5) | 176 (26.2) | 16 (2.4) | 9.508 | 0.009 | 1138 (84.5) | 208 (15.5) | 7.882 | 0.005 |
| Control | 508 (77.3) | 144 (21.9) | 5 (0.8) | 1160 (88.3) | 154 (11.7) | |||||
| rs712 (G>T) | PTC | 394 (58.5) | 244 (36.6) | 35 (5.2) | 15.802 | <0.001 | 1032 (76.7) | 314 (23.3) | 10.666 | 0.001 |
| Control | 451 (68.6) | 173 (26.3) | 33 (5.0) | 1075 (81.8) | 239 (18.2) | |||||
| rs7315339 (T>C) | PTC | 532 (79.0) | 140 (20.8) | 1 (0.1) | - | 0.228a | 1204 (89.5) | 142 (10.5) | 0.807 | 0.369 |
| Control | 509 (77.5) | 143 (21.8) | 5 (0.8) | 1161 (88.4) | 153 (11.6) | |||||
| rs12628 (T>C) | PTC | 380 (56.5) | 262 (38.9) | 31 (4.6) | 0.944 | 0.624 | 1022 (75.9) | 324 (24.1) | 0.390 | 0.532 |
| Control | 365 (55.6) | 254 (38.7) | 38 (5.8) | 984 (74.9) | 330 (25.1) | |||||
| rs14804 (C>T) | PTC | 638 (94.8) | 35 (5.2) | 0 (0) | - | 0.483a | 1311 (97.4) | 35 (2.6) | 0.087 | 0.769 |
| Control | 627 (95.4) | 29 (4.4) | 1 (0.2) | 1283 (97.6) | 31 (2.4) | |||||
| rs2273267 (T>A) | PTC | 360 (53.5) | 279 (41.5) | 34 (5.1) | 3.358 | 0.187 | 999 (74.2) | 347 (25.8) | 0.810 | 0.368 |
| Control | 347 (52.8) | 261 (39.7) | 49 (7.5) | 955 (72.7) | 359 (27.3) | |||||
Notes: Data were presented as number (proportion). P values were calculated by χ2 test or Fisher's exact test. a, Fisher's exact test. 1, reference allele; 2, variant allele; 1/1, homozygous wild; 1/2, heterozygous; 2/2, homozygous mutational.
Abbreviations: PTC, papillary thyroid carcinoma.