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Knockdown of USP37 induced cellular apoptosis and decreased tumor growth in nude mice. (A) Flow cytometry showed that USP37 downregulation caused the apoptosis of MCF-7 and MCF-7/ADR cells. (B-C) Tumors were removed from the nude mice and taken photograph to show the sizes of xenografted tumors. Statistical analysis of the weight of tumor excised from BALB/c nude mice at day 21. *P<0.05 vs. shScramble group. (D) Images of HE staining in different groups. (Scale bars: 100 µm).
