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. 2021 Jan 1;18(2):325–334. doi: 10.7150/ijms.54301

Figure 6.

Figure 6

Knockdown of USP37 reduced the chemoresistance of MCF-7 cells to adriamycin. The transfected MCF-7 cells were pretreated with adriamycin (0.2 µg/ml). After the shScramble goup and the shUSP37#1 group were treated with dimethylsulfoxide (DMSO) or adriamycin for 48 hrs, (A) representative images of MCF-7 cells (Scale bars: 100 µm) and Tunel assay revealed the phenomenon of cellular apoptosis (Scale bars: 200 µm). Quantitative analysis results of TUNEL-positive signals are shown on the right. *P<0.05 vs. shUSP37#1 group. (B) Western blotting assay was used to evaluate the protein expression levels of apoptosis-related genes (Bax, Bcl-2, cleaved caspase 3) and β-tublin. *P<0.05 vs. shScramble group.