FIGURE 4.

p38 MAPK expression in the nucleus accumbens shell (n = 4‐5). Rats conditioned with cocaine CPP and injected with vehicle, corticotropin‐releasing factor (CRF), or alpha‐helical CRF prior to each cocaine conditioning. CRF + [social] is a group of rats conditioned with cocaine that received intracerebroventricular (icv) injections of CRF prior to cocaine conditioning but also had the opportunity for social interaction in the alternative compartment of the CPP. ^* P < .05, ^*** P < .001, different from VEH; ^### P < .001, different from CRF. VEH (n = 4), CRF (n = 5), alpha‐helical CRF (n = 5), CRF + [Social] (n = 5). Statistical test: one‐way analysis of variance (ANOVA) followed by Tukey's post hoc test. α CRF, alpha‐helical CRF; COC, cocaine CPP; Control, Sal CTR; CPP, conditioned place preference; SI, Social CPP; VEH, vehicle