Table 2.
clinical and biological characteristics of the 402 children with severe malaria and the 315 for whose blood products have been ordered, Regional Hospital of Koudougou, Burkina Faso, 2016
| Parameter | Total (N=402) | Blood ordering | p-value | |||
|---|---|---|---|---|---|---|
| Yes (N=315) | No (N=87) | Odd-ratio | [95%CI] | |||
| n; (% column) | n; (% row) | n; (% row) | ||||
| Onset of symptoms in day (mean ± sd) ǂ | 3.2±1.6 | 3.3±1.7 | 3.0±1.5 | - | - | 0.06 |
| Severe malnutritionᶲ | 85 (21.1) | 78 (91.8) | 7 (8.2) | 3.1 | 1.8-5.5 | <0.001 |
| Hemoglobin level in g/L (mean ± sd) ǂ | 51.4±22.2 | 42.3±12.7 | 84.0±18.4 | - | - | <0.001 |
| Hemoglobin level range (g/L)ᶲ | ||||||
| <40 | 132 (32.8) | 132 (100.0) | 0 (0.0) | 1 | - | |
| 40 – 60 | 160 (39.8) | 153 (95.6) | 7 (4.4) | 58.3 | 24.5-138.6 | <0.001 |
| >60 | 110 (27.4) | 30 (27.3) | 80 (72.7) | 1 | - | - |
| Parasitic density ((mean ± sd) x 1000) ǂ | 36.83±71.86 | 35.55±69.19 | 41.63±81.04 | - | - | 0.5 |
| Indicators of severe malariaᶲ | ||||||
| Cerebral malaria | 16 (4.0) | 10 (62.5) | 6 (37.5) | 0.4 | 0.1-1.2 | 0.1 |
| Repeated convulsions | 66 (16.4) | 25 (37.9) | 41 (62.1) | 0.1 | 0.1-0.2 | <0.001 |
| Impaired consciousness | 68 (16.9) | 44 (64.7) | 24 (35.3) | 0.5 | 0.3-1.0 | 0.003 |
| Prostration | 72 (17.9) | 50 (69.4) | 22 (30.6) | 0.4 | 0.2-0.7 | 0.04 |
| Respiratory distress | 51 (12.7) | 44 (86.3) | 7 (13.7) | 1.8 | 0.8-4.3 | 0.1 |
| Shock | 12 (3.0) | 11 (91.7) | 1 (8.3) | 3.1 | 0.4-24.4 | 0.3 |
| Abnormal bleeding | 1 (0.2) | 1 (100.0) | 0 (0.0) | 1 | - | - |
| Macroscopic hemoglobinuria | 21 (5.2) | 18 (85.7) | 3 (14.3) | 1.7 | 0.5-5.9 | 0.4 |
| Clinical jaundice | 26 (6.5) | 14 (53.8) | 12 (46.2) | 0.3 | 0.1-0.6 | 0.003 |
| Severe anemia | 261 (64.9) | 261 (100.0) | 0 (0.0) | 1 | - | - |
| Renal impairment | 5 (1.2) | 3 (60.0) | 2 (40.0) | 0.4 | 0.1-2.5 | 0.3 |
| Hyperparaitemia | 21 (5.2) | 16 (76.2) | 5 (23.8) | 0.9 | 0.3-2.5 | 0.8 |
| Hypoglycemia | 27 (6.7) | 17 (63.0) | 10 (37.0) | 0.4 | 0.2-1.0 | 0.04 |
| In-hospital length of stay (day) (mean ± sd) ǂ | 3.3±2.2 | 3.5±2.3 | 3.3±2.0 | - | - | 0.9 |
| Deathᶲ | 23 (5.7) | 17 (73.9) | 6 (26.1) | 0.8 | 0.3-2.0 | 0.6 |
ǂ ANOVA; ᶲ Chi-squared or Fischer test; g=gramm; L=liter; sd=standard deviation