Table 1.
Baseline subjects characteristics
| AM | PM | |
|---|---|---|
| Sample size | 12 | 20 |
| T2D subjects | 4 | 8 |
| NAFL subjects | 3 | 6 |
| Healthy obese subjects | 5 | 6 |
| Age (year) | 61 ± 5 | 57 ± 7 |
| Body weight (kg) | 94.7 ± 11.7 | 98.1 ± 10 |
| BMI (kg/m2) | 30.3 ± 2.6 | 29.8 ± 2.3 |
| Fat mass (kg) | 27.4 ± 4.3 | 28.8 ± 5.6 |
| Fat percentage (%) | 28.6 ± 2.3 | 29 ± 3.2 |
| Trunk fat mass (kg) | 16.0 ± 2.5 | 16.2 ± 3.4 |
| Fat‐free mass (kg) | 65.4 ± 7.2 | 67.1 ± 5.1 |
| VO2max (ml/kg/min) | 26 ± 4.0 | 26.5 ± 4.5 |
| Wmax (W/kg) | 1.9 ± 0.4 | 2.0 ± 0.3 |
| Fasting glucose (mmol/l) | 6.7 ± 2.1 | 6.8 ± 2.1 |
| Fasting‐free fatty acids (µmol/l) | 566 ± 171 | 615 ± 169 |
| Clamp data | ||
| Basal EGP (µmol/min/kgFFM) | 7.4 ± 1.5 | 8.1 ± 3.5 |
| Basal Rd (µmol/min/kgFFM) | 7.8 ± 1.8 | 7.9 ± 3.6 |
| Basal CHOox (µmol/min/kgFFM) | 5.9 ± 3.9 | 5.3 ± 2.6 |
| Insulin‐induced suppression of plasma FFA (%) | −62.6 ± 9.5 | −61.6 ± 16.0 |
| Insulin‐induced suppression of EGP (%) | −41.8 ± 26.3 | −32.2 ± 28.9 |
| Delta Rd (µmol/min/kgFFM) | 16.9 ± 11.2 | 15.2 ± 9.0 |
| Delta NOGD (μmol/min/kgFFM) | 8.9 ± 7.2 | 8.2 ± 6.2 |
Data are displayed as mean ± SD. BMI, body mass index; VO2max, maximal aerobic capacity; Wmax, maximal power output; EGP, endogenous glucose production; Rd, glucose disposal; CHOox, carbohydrate oxidation; FATox, fat oxidation; FFA, free fatty acids; NOGD, non‐oxidative glucose disposal. Insulin‐induced suppression of EGP and plasma FFA was measured at 10 mU/m2/min. Delta Rd was calculated as the difference between basal and insulin‐stimulated glucose disposal at 40 mU/m2/min infusion rate.