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. 2020 Oct 23;3(4):245–259. doi: 10.1093/pcmedi/pbaa037

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© The Author(s) 2020. Published by Oxford University Press on behalf West China School of Medicine & West China Hospital of Sichuan University.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Differentially expressed miRNAs in lacto, semi, and vegan vegetarians compared to NV. Volcano plots showing the differentially expressed miRNAs between (A) Lacto and NV; (B) Semi and NV; and (C) Vegan and NV. –log10(padj) ≥ 0.52 (padj ≤ 0.3) and |log2FC| ≥ 0.5 were marked as the significant threshold. The significant DE miRNAs (top 10 DE miRNA by |log2FC| if more than 10 significant DE miRNAs present) are highlighted. Bar graphs showing the top 10 enriched canonical pathways between (D) Lacto and NV; (E) Semi and NV; (F) Vegan and NV. UpSet plots showing the number of significantly (G) upregulated; and (H) downregulated DE miRNAs across four comparisons (Lacto vs. NV, Semi vs. NV, Vegan vs. NV and V vs. NV in general), and the overlapping between each set of miRNAs. (I) Most distinctive enrichments in canonical pathway among three vegetarian subgroups. V: vegetarians, NV: non-vegetarians, Lacto: lacto-ovo-vegetarians; Semi: semi-vegetarians.