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. 2020 Oct 23;3(4):245–259. doi: 10.1093/pcmedi/pbaa037

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© The Author(s) 2020. Published by Oxford University Press on behalf West China School of Medicine & West China Hospital of Sichuan University.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Differentially expressed miRNAs in males and females. Volcano plot showing differentially expressed miRNAs between V and NV in (A) males and (B) females. –log10(padj) ≥ 0.52 (padj ≤ 0.3) and |log2FC| ≥ 0.5 were marked as the significant threshold. The significant DE miRNAs (top 10 DE miRNA by |log2FC| if more than 10 significant DE miRNAs present) are highlighted. Bar graphs showing the top 10 enriched canonical pathways between V and NV in (C) males and (D) females. UpSet plots showing the number of significantly (E) upregulated, and (F) downregulated DE miRNAs across three comparisons (V vs. NV in males, V vs. NV in females, and V vs. NV in general), and the overlapping between each set of miRNAs. (G) Most distinctive enrichments in canonical pathway between male and female vegetarians. V: vegetarians, NV: non-vegetarians, M: males, F: females.