Table 2.
Corneal Confocal Microscopic Parameters, Peripapillary RNFL Thickness, and Disease Severity Scores in Patients With Multiple Sclerosis With and Without a Worsening in EDSS Score Over 2 Years
| Patients with Worsening EDSS (n = 15) | Patients without Worsening EDSS (n = 16) | |||||
|---|---|---|---|---|---|---|
| Characteristic | Baseline | Follow-up | P Value | Baseline | Follow-up | P Value |
| CNFD (No./mm2) | 29.6 ± 7.4 | 26.0 ± 7.1 | 0.09a | 24.4 ± 6.2 | 25.5 ± 6.2 | 0.43a |
| CNBD (No./mm2) | 41.1 ± 19.3 | 30.3 ± 14.1 | 0.05a | 35.3 ± 20.7 | 33.8 ± 14.7 | 0.76a |
| CNFL (mm/mm2) | 17.1 ± 2.8 | 15.0 ± 2.4 | <0.001 a | 15.1 ± 3.3 | 15.2 ± 3.2 | 0.86a |
| CTBD (No./mm2) | 61.7 ± 25.4 | 45.1 ± 18.6 | 0.01 a | 50.9 ± 25.6 | 51.4 ± 21.4 | 0.93a |
| CNFA (µm/mm2) | 7360.0 ± 1141.9 | 6153.3 ± 1860.1 | 0.02 a | 6743.7 ± 1908.6 | 5887.5 ± 1600.4 | 0.08a |
| CNFW (µm) | 22.2 ± 1.6 | 21.2 ± 0.9 | 0.04 a | 21.9 ± 1.3 | 21.2 ± 1.7 | 0.07a |
| DC density (No./mm2) | 20.3 (6.7–39.3) | 52.7 (4.7–111.0) | 0.04 b | 28.4 (4.9–35.5) | 14.5 (4.8–45.5) | 0.68b |
| RNFL (µm) | 85.4 ± 12.2 | 83.9 ± 12.4 | 0.02 a | 82.8 ± 15.5 | 81.9 ± 16.0 | 0.09a |
| EDSS | 3.0 (2.0–3.5) | 3.5 (2.5–4.0) | <0.001 b | 3.0 (2.0–3.9) | 2.8 (2.0–3.8) | 0.10b |
| MSSS | 4.4 ± 1.9 | 4.8 ± 1.4 | 0.08a | 4.7 ± 1.8 | 3.9 ± 1.6 | <0.001 a |
Data are expressed as mean ± SD for CNFD, CNBD, CNFL, CTBD, CNFA, CNFW, RNFL and MSSS, and median (interquartile range) for DC density and EDSS. The bold P values represent statistically significant differences.
a
Paired samples t-test.
b
Wilcoxon signed rank test.