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. 2020 Dec 9;10:578963. doi: 10.3389/fonc.2020.578963

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Copyright © 2020 Gong, Shao, Yang, Song, He, Zeng, Huang, Wei and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-expression of APC and METTL14, ZC3H13. (A, B) The correlation between APC and METTL14, ZC3H13 mRNA expression determined using GEPIA. (C) The relationship between APC and METTL14, ZC3H13 in breast cancer analyzed using bc-GenExMiner v4.0. (D, E) The correlation between APC and METTL14, ZC3H13 mRNA expression via the cBioPortal online database (TCGA, PanCancer Atlas). (F) Heat map of APC expression and METTL14, ZC3H13 mRNA expression across PAM50 breast cancer subtypes in the TCGA using UCSC Xena. (G) The expression of APC in cancer tissues and normal control in TCGA database generated by TIMER database. (F) The RFS curves of APC gene expression in four types breast cancer patients, including luminal type A, luminal type B, HER2 enriched type and triple negative type (TNBC). ***P < 0.001, **P < 0.01, *P < 0.05.