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(A) Overlap among three genome-wide assays for sites nominated across eight gRNAs. (B) Edit distances of nominated sites across eight gRNAs shared among and unique to different homology-independent nomination methods. The x-axis represents overlap with the three genome-wide assays. The y-axis shows the sum of mismatches and gaps for a site when aligned to the gRNA sequence. All three distributions were significantly different from each other (Wilcoxon p-value <2e-16).
