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. Author manuscript; available in PMC: 2020 Dec 23.
Published in final edited form as: Chem Res Toxicol. 2019 Nov 7;32(11):2238–2249. doi: 10.1021/acs.chemrestox.9b00270

Table 4:

Synthetic Analogues of Tryptanthrin (3)

graphic file with name nihms-1652033-t0003.jpg
Substitution Yield
3 R2=R3=R8=R9=H 12%
3a R2=R8=F, R3=R9=H 16%
3b R2=R8=Cl, R3=R9=H 10%
3c R2=R8=Br, R3=R9=H 12%
3d R2=R8=CH3, R3=R9=H 15%
3e R2=R8=COOCH3, R3=R9=H 27%
3f R2=R8=H, R3=R9=Br 13%
3g R2=R8=H, R3=R9=COOCH3 18%
3h R2=R8= R9=H, R3=Br 12%