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. Author manuscript; available in PMC: 2020 Dec 23.
Published in final edited form as: Chem Res Toxicol. 2019 Nov 7;32(11):2238–2249. doi: 10.1021/acs.chemrestox.9b00270

Table 6:

EC50values for the induction of AhR-dependent gene expression in human (HG2L7.5c1) and mouse (H1L7.5c3) hepatoma cell lines by tryptanthrins.

graphic file with name nihms-1652033-t0005.jpg
EC50, 6h Human Cells EC50, 6h Mouse Cells
3 1.7×10−7 8.1×10−7
3a 5.4×10−8 2.0×10−6
3b 8.4×10−8 9.1×10−7
3c 5.6×10−7 3.6×10−6
3d 6.8×10−8 7.2×10−7
3e 4.5×10−7 3.7×10−6
3f 4.9×10−10 3.9×10−7
3g Inactive Inactive
3h 5.7×10−11 >1.0×10−6
TCDD 5.7×10−10 1.0×10−10