Table 3.

Adjusted Linear Regression Models: Association of BAUD Intensity and >6 Months of MAUD with Pre- to Post-Treatment Change in CD4, Log VL, VACS Index Score 2.0, and ARV Adherence^*

	Detectable VL		Undetectable VL
Treatment Intensity	Coef	95% CI	Coef	95% CI
CD4 change	n=2139		n=2802
>6 Months of MAUD	27.09	1.40–52.79	−10.5	−31.3–10.3
1 Day Only (referent group)
Minimal	15.77	−1.06–32.61	2.05	−12.76–16.86
Moderate	30.11	9.20–51.01	−2.75	−23.30–17.80
Intensive	27.60	−10.20–65.41	−10.4	−53.53–32.64
	P=.03		P=.9
Log HIV-1 RNA change	n=2176		n=2869
>6 Months of MAUD	−0.16	−0.32–0.01	−0.08	−0.23–0.06
1 Day Only (referent group)
Minimal	−0.07	−0.18–0.04	−0.02	−0.13–0.08
Moderate	0.01	−0.13–0.15	0.06	−0.09–0.20
Intensive	−0.40	−0.66–(−0.14)	0.03	−0.27–0.33
		P=.01		P=.7
VACS Index Score 2.0 change	n=2053		n=2460
>6 Months of MAUD	−0.94	−2.69–0.81	−.30	−1.42–0.83
1 Day Only (referent group)
Minimal	−0.55	−1.67–0.57	−0.18	−0.97–0.60
Moderate	−0.71	−2.11–0.69	0.62	−0.48–1.71
Intensive	−3.79	−6.45–(−1.13)	−0.03	−2.25–2.20
	P=.047		P=.5
ARV Adherence change**	n=1649		n=2827
>6 Months of MAUD	0.05	0.02–0.08	0.04	0.02–0.05
1 Day Only (referent group)
Minimal	0.01	−0.01–0.03	−0.00	−0.01–0.01
Moderate	0.03	0.00–0.05	−0.01	−0.02–0.01
Intensive	0.09	0.04–0.15	0.08	0.05–0.12
	P=.004		P<.001

^*Models are adjusted for age and race/ethnicity, gender, smoking, HCV, drug diagnosis, severe mental illness (SMI), AUDIT-C, and for corresponding models, number of days between pre and post values for log VL, CD4, and VACS Index change.