Fig 3. Paternal effect of H2A.B KO on embryo fitness.
(A) Fraction (%) of severely delayed or fully resorbed conceptuses dissected at embryonic day 14.5 (E14.5) (also see S3 Data). Total number of pups for each cross type is indicated at the bottom of each bar. Bars are colored according to each parental cross. p-value is based on a chi-squared test (vs. expected WT). Mating schemes are indicated as dam × sire. (B) Embryo (top) and placenta (bottom) weight distributions for male (left) and female (right) conceptuses (also see S4 Data). Parental cross is shown at the bottom and embryo genotype is shown at the top of each graph. XKO indicates H2A.B KO chrX. Dots are colored according to parental crosses. Significance of Kruskal–Wallis ANOVA test is shown * p < 0.01, ** p < 0.001, *** p < 0.0001, and **** p < 0.00001. (C) Schematic of H2A.B paternal effect on embryo weights. Mating schemes are indicated as dam x sire. chrX, X chromosome; KO, knockout; WT, wild-type.