Figure 3.
Different gating modes determining the INa,early and INa,late. (a) Schematic illustrations of the three Nav1.5 gating modes. INa,early is determined by the transient mode. Burst mode and late scattered mode are responsible for INa,late, however, the late scattered mode is the main gating for INa,late. (b) Representative electrophysiological recording of the INa. Blue shows the early, peak component of the INa (INa,early), while red shows the sustained, late component of the current (INa,late). C, closed and O, opened