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. Author manuscript; available in PMC: 2022 Jan 15.
Published in final edited form as: Brain Res. 2020 Nov 26;1751:147208. doi: 10.1016/j.brainres.2020.147208

Figure 4. Deposition of Fg and expression of PrPC, and their co-localization in brain of mice treated with fibrinogen antisense oligonucleotide (Fg-ASO) after CCI.

Figure 4.

A) Examples of images showing expression of PrPC (green) and deposition of Fg (red), and their co-localization in mouse cortical vessels. Lycopersicon esculentum lectin, a marker of endothelium is shown in blue. Samples were collected 14 days after CCI or sham-operation.

B) Data analysis of fluorescence intensities of Fg and PrPC (presented as fluorescence intensity) are shown in the upper two plots. Co-localization of Fg and PrPC was assessed as a number of spots of co-localized respective fluorophores.

P<0.05 in all; * - vs. Sham Control-ASO, † - vs. CCI Control-ASO n=4/group. Mann-Whitney statistical test was used to define the difference between the groups.