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. 2020 Dec 23;15(12):e0244215. doi: 10.1371/journal.pone.0244215

Fig 1. Unexpectedly high dystrophin levels detected in the heart of untreated and AON treated hDMDdel52/mdx mice.

Fig 1

A. Wes capillary immunoassay analysis revealed two groups of mice. Most mice had very low dystrophin levels (0.2–1.5%, mean: 0.7, standard deviation (SD): 0.2, group 1), while some treated and untreated mice had dystrophin levels in the range of 8.6–21.6% (mean: 13.4, SD: 3.0, group 2). B. Droplet digital qPCR revealed that exon skipping levels were comparable between the groups and therefore could not account for the differences observed in dystrophin protein levels. (Group 1: 0.1–4.8%, mean: 1.7, SD: 1.4 group 2: 0.2–4.2%, mean: 2.2, SD: 1.4). WT; wild type.