Fig 8. A schematic representation of hDMD gene constructs on mouse chromosome 5 of the hDMDdel52/mdx and hDMDdel52-53/mdx mice.

A. The figure represents the tail-to-tail duplication of the hDMD gene, and the genetic rearrangements which include a partial deletion of exon 52 and an inversion of part of intron 51 in the hDMDdel52/mdx mouse. The green area including intron 51 and artificial elements could not be confirmed by sequencing. B. Because the hDMD gene in the hDMDdel52-53/mdx mouse was not sequenced, the schematic representation is mostly hypothetical but ddPCR results revealed that a ~65 kb genomic deletion including exon 52–53 (Fig 3) occurred in one hDMD copy and the other three copies remained intact.