Table 6.
Aerodynamic Size distribution of different formulations of the DPIs using Andersoncascade impactor (n = 3)
| Fine Particle Fraction (FPF) (%) Mean ± SD |
Drug deposition (%)
|
Lactose (%) | No. | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Stage 8 (0.52 µm) Mean ± SD | Stage 7 (0.93 µm) Mean ± SD | Stage 6 (1.55 µm) Mean ± SD | Stage 5 (3.5 µm) Mean ± SD | Stage 4 (5.0 µm) Mean ± SD | Stage 3 (9.8 µm) Mean ± SD | Stage 2 (14.8 µm) Mean ± SD | Stage 1 (21.3 µm) Mean ± SD | |||
| 35.71 ± 1.81 | 32.54 ± 3.62 | 26.50 ± 3.42 | 6.48 ± 1.31 | 2.73 ± 0.62 | 2.44 ± 0.86 | 0.67 ± 0.12 | ND1 | ND1 | 1 | 1 |
| 53.96 ± 3.67 | 25.87 ± 4.72 | 24.61 ± 2.65 | 17.93 ± 3.42 | 11.42 ± 3.15 | 9.27 ± 2.38 | 4.68 ± 1.47 | 1.31 ± 0.18 | ND1 | 5 | 2 |
| 72.57 ± 4.33 | 10.31 ± 3.57 | 23.52 ± 4.11 | 27.10 ± 3.95 | 21.95 ± 4.83 | 4.39 ± 2.52 | 5.61 ± 1.83 | 2.24 ± 0.68 | 2.93 ± 0.73 | 10 | 3 |
| 54.99 ± 3.04 | 2.63 ± 0.96 | 10.88 ± 2.75 | 18.43 ± 3.52 | 25.68 ± 2.41 | 11.46 ± 3.78 | 17.13 ± 3.27 | 7.49 ± 1.59 | 8.74 ± 2.86 | 15 | 4 |
| 22.03 ± 2.53 | ND1 | 4.94 ± 1.21 | 7.37 ± 3.64 | 9.72 ± 2.31 | 15.53 ± 3.64 | 18.90 ± 2.75 | 22.83 ± 3.56 | 20.37 ± 3.63 | 20 | 5 |
1Not Detected.