Table 2.
Characterization of the prepared plain/medicated sponges.
| Parameter |
Muco-adhesion time (minutes) |
Ex-vivo muco-adhesion force (N) | ||||
|---|---|---|---|---|---|---|
| Formula | Surface pH | Porosity (%) | Swelling index | In-vivo | Ex-vivo | |
| Plain sponge | ||||||
| C0.5 | 6.36 ± 0.026 | 21 ± 1.2 | 0.48 ± 0.01 | 60 ± 0.547 | **NA | **NA |
| C1 | 6.35 ± 0.037 | 23.5 ± 0.9 | 3.92 ± 0.06 | 120 ± 1.1136 | **NA | **NA |
| C2 | 6.33 ± 0.01 | 26 ± 1.5 | 5.23 ± 0.09 | 116 ± 1.11 | **NA | **NA |
| M1 | 6.79 ± 0.03 | 35 ± 2.5 | 3.788 ± 0.1 | 15 ± 2.64 | **NA | **NA |
| *Medicated sponge | ||||||
| mC0.5 | 6.29 ± 0.091*** | 22 ± 0.88*** | 0.55 ± 0.04*** | 59 ± 1.62 *** | 90 ± 0.53 | 0.014 ± 0.0115 |
| mC1 | 6.26 ± 0.066*** | 23.8 ± 1.1*** | 3.68 ± 0.03*** | 123 ± 0.113*** | 136 ± 0.197 | 0.032 ± 0.0057 |
| mC2 | 6.30 ± 0.042*** | 25.7 ± 1.8*** | 5.70 ± 0.11*** | 115 ± 0.813*** | 155 ± 1.537 | 0.09 ± 0.002 |
| mM1 | 6.68 ± 0.12*** | 36.2 ± 1.7*** | 3.529 ± 0.8*** | 19 ± 0.48*** | 30 ± 0.1 | 0.06 ± 0.002 |
*Medicated sponge contains 10 mg% miconazole nitrate and 6 mg% tenoxiam. **NA means Not Applied experiment. *** Symbol means results insignificantly different (p > .05) from plain sponges.