Table 5.
Particulate Matter and Oxidative Stress: Literature Summary
| Authors, Year | Methods | Main Findings |
|---|---|---|
| Jantzen et al. 2018 | 23 healthy elderly subjects | CD34+KDR+ late endothelial progenitor cells decreased by 48% in the blood |
| Li et al. 2017 | Controlled human exposure study | PM2.5 increased markers of oxidative stress, including serum malondialdehyde, iso-prostaglandin F2α, superoxide dismutase, and 8-hydroxy-2-deoxyguanosine |
| Zhang et al. 2016a | 97 elderly subjects living in the Los Angeles area | Demonstrated associations among airway oxidative stress and inflammation with traffic-related air pollutants, ultrafine particles and transition metals |
| Zhang et al. 2016b | 93 elderly subjects living in the Los Angeles area | Reactive hyperemia index inversely associated with traffic related pollutants and other mobile-source components, as well as oxidative potential of transition metals and PM<2.5 |
| Liu et al. 2015 | Controlled human exposure study | Increased levels of urinary 8-OHdG in healthy nonsmoking adults exposed to coarse (2.5–10 μm) or ultrafine concentrated ambient particles |
| Wang et al. 2012 | Human lung EC monolayer | PM induces marked increases in vascular permeability via ROS-mediated calcium leakage |
| Huang et al. 2012 | 125 Beijing participants in the during-Olympic Games period | Change in PM caused decrease in levels of airway inflammation and urinary 8-OHdG |
| Miller et al. 2009 | Effects of DEP (10–100 microg/mL) in isolated rat aortic rings | DEP caused oxidative stress through oxygen-centered free radicals that reduce bioavailability of endothelium-derived NO |
| Hartz et al. 2008 | Isolated rat brain capillaries exposed to DEPs | DEPs, alters blood-brain barrier function through oxidative stress and proinflammatory cytokine production |
| Sun et al. 2008 | Sprague-Dawley rates exposed to PM2.5 | Upregulation of Rho/ROCK pathway, activated by reactive oxygen species, causes increased vascular tone |
| Nurkiewicz et al. 2006 | Rats intratracheally indussed with residual oil fly ash (ROFA) or titanium dioxide | Impaired endothelium-dependent dilation, PMNL adhesion, MPO deposition, and oxidative stress |
| Taniyama et al. 2003 | Review | ROS plays a central role in normal physiology, and contributes to vascular disease |
| Gurgueira et al. 2002 | Rat model of short-term concentrated ambient particle exposure | Tissue-specific increases in superoxide dismutase and catalase activity |
| Bai et al. 2001 | Human pulmonary artery endothelial cells exposed to diesel exhaust particles | Endothelial cell damage caused by DEP extracts is likely mediated by oxygen derived free radicals |