FIG. 6.

Schematic illustration of three-dimensionally confined hydrodynamic micro-vortices. WBC is the white blood cell and RBC is the red blood cell. (a) Cell trapping mode where d_gap is smaller than the radius of the cells and all the cells are trapped within the micro-vortices; (b) cell release mode where d_gap is comparable to the radius of the cells, which allows one-to-one encapsulation; (c) d_gap is comparable to the radius of blood platelets that are released whereas RBCs and WBCs are trapped within the micro-vortices; (d) by increasing d_gap, platelets, RBCs and WBCs are released in ascending order of their sizes. Reproduced with permission Kamalakshakurup and Lee, Lab Chip 17, 4324 (2017).⁸⁵ Copyright 2017 Royal Society of Chemistry.