Fig. 5:

Effect of CCR2 inhibitor INCB3334 on behaviors induced by local inflammation of the dorsal root ganglion (“LID”). Baseline behaviors were measured on 2 days prior to and just prior to the DRG inflammation surgery on day 0. INCB3334 or vehicle was injected intravenously on days −1, 0, and 1 (blue arrows; behaviors measured 2 hours later). A, von Frey threshold on the ipsilateral side; B, ipsilateral guarding score (maximum score is 3). ###, p<0.001; significant overall effect for INCB3344/vehicle factor (2 way repeated measures ANOVA); F_(1,14) = 49.9 (A); 18.9 (B). In both panels the interaction effect was also significant. **, p<0.01; ***,p<0.001; significant difference between the groups at the indicated time point (Bonferroni's multiple comparisons posttest). N = 8 mice/group, wildtype, both sexes. Data separated by sex can be found in supplemental Fig. A5.