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Activation of SIRT1 decreases tau acetylation and tau phosphorylation in the hippocampus of aged rats exposed to anesthesia and surgery. (a)–(c) Representative immunoblot bands and the corresponding densitometry analysis of ac-tau (k280), ac-tau (k686) expression normalized to β-actin, and p-tau (AT8) expression normalized to total tau. Data are presented as the mean ± SD. n = 6 per group.
