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Activation of SIRT1 decreased the LPS+sevoflurane-conditioned medium-induced tau acetylation and tau phosphorylation in primary hippocampal neurons. (a)–(d) Representative immunoblot bands and the corresponding densitometry analysis of SIRT1, ac-tau (k280), ac-tau (k686) expression normalized to β-actin, and p-tau (AT8) expression normalized to total tau. Data are presented as the mean ± SD. n = 6 per group.
