Table 5.

The topological characteristics of the top 30 nodes in the PPI network of EC-induced NSPC genetic alterations. NA means not overlapped between the EC-PPI and NSPC-PPI networks.

Gene	Overlap	Regulate	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Topological coefficient
Gapdh	NA	Down	129	2.303797	0.21952	0.434066	0.040603
Fn1	NA	Down	83	2.586881	0.062983	0.386566	0.054676
Vegfa	NA	Down	64	2.638665	0.041079	0.37898	0.063087
Decr1	NA	Down	59	2.609896	0.066189	0.383157	0.059219
Cd44	NA	Down	57	2.693901	0.029026	0.371209	0.069522
Ccnd1	NA	Down	54	2.703107	0.040282	0.369945	0.065015
Gfap	NA	Down	51	2.663982	0.042334	0.375378	0.070175
Gad1	NA	Up	47	2.837745	0.023163	0.352393	0.075753
Cxcr4	NA	Down	45	2.805524	0.015376	0.35644	0.091761
Pkm	NA	Down	45	2.780207	0.042856	0.359685	0.072881
Anxa5	NA	Down	41	2.817031	0.007322	0.354984	0.091351
Timp1	NA	Down	41	2.805524	0.010114	0.35644	0.09083
Agt	NA	Down	40	2.857307	0.014755	0.34998	0.0945
Cav1	NA	Down	40	2.788262	0.021742	0.358646	0.081866
H6pd	Overlap	Down	39	2.905639	0.018002	0.344158	0.081197
Calb1	NA	Up	39	2.827388	0.022978	0.353683	0.082931
Ctgf	NA	Down	38	2.79977	0.019484	0.357172	0.08851
Pdgfrb	NA	Down	38	2.840046	0.010704	0.352107	0.092062
Snap25	NA	Up	38	2.840046	0.026457	0.352107	0.071554
Fos	NA	Down	37	2.757192	0.026678	0.362688	0.086654
Gad2	NA	Up	37	2.842348	0.016537	0.351822	0.0868
Anxa1	NA	Down	36	2.912543	0.010209	0.343343	0.091158
Tpi1	NA	Down	36	2.905639	0.015808	0.344158	0.086608
Gria1	NA	Up	35	2.837745	0.033782	0.352393	0.079529
Ldha	NA	Down	35	2.933257	0.010636	0.340918	0.096276
Thy1	NA	Down	35	2.886076	0.018426	0.346491	0.090796
Tubb3	NA	Up	35	2.829689	0.013785	0.353396	0.087982
Npy	NA	Up	34	2.906789	0.010344	0.344022	0.099831
Sst	NA	Up	34	2.921749	0.012787	0.342261	0.101852
Gng3	NA	Up	32	3.179517	0.007673	0.314513	0.107118