Table 4.
Univariate and multivariate analyses of predictive factors for successful HFNC
| Variable | Odds ratio | 95% CI | p value |
|---|---|---|---|
| Univariate analysis of predictive factors of the outcome of HFNC | |||
| Age, years | 0.871 | 0.819–0.926 | <0.001 |
| Sex, male | 0.400 | 0.178–0.899 | 0.027 |
| Comorbidities | 0.700 | 0.313–1.565 | 0.385 |
| Smoking, current or former | 1.086 | 0.297–3.973 | 0.901 |
| LYM (× 109/ L; normal range 1.1–3.2) | 1.045 | 0.235–4.657 | 0.954 |
| D–D (ug/ml; normal range 0.0–0.5) | 1.001 | 0.947–1.058 | 0.974 |
| CRP (mg/L; normal range 0.0–5.0) | 0.999 | 0.988–1.011 | 0.922 |
| PaO2/FiO2 at HFNC application | 1.002 | 0.985–1.018 | 0.830 |
| PSI | 0.931 | 0.903–0.960 | <0.001 |
| APACHE-II | 0.822 | 0.710–0.951 | 0.008 |
| SOFA | 0.501 | 0.338–0.744 | 0.001 |
| 6h ROX index >5.55, yes | 8.643 | 3.342–22.354 | <0.001 |
| Multivariate analysis of predictive factors of the outcome of HFNC | |||
| Age, years | 0.837 | 0.745–0.940 | 0.003 |
| Sex, male | 0.172 | 0.038–0.790 | 0.024 |
| PSI | 1.004 | 0.939–1.074 | 0.903 |
| APACHE-II | 1.166 | 0.858–1.585 | 0.326 |
| SOFA | 0.389 | 0.203–0.745 | 0.004 |
| 6h ROX index >5.55, yes | 17.821 | 3.741–84.903 | <0.001 |
HFNC high-flow nasal cannula oxygen therapy, LYM lymphocyte number, D-D, D-dimer, CRP c-reaction protein, PSI pneumonia severity index, APACHE-II Acute Physiology and Chronic Health Evaluation II, SOFA Sepsis-related Organ failure Assessment, ROX index Respiratory rate-oxygenation index