TABLE 8.
textitIn vivo studies of 3D structures/organoids transplantation.
| References | Product | Cell type | Description | Animal | Cell survival |
| Gonzalez-Cordero et al., 2013 | – | mESC | Transplantation of photoreceptors from an organoid model. | Mouse | 3 w |
| Assawachananont et al., 2014 | Matrigel | mESC miPSC | Transplantation of retinal sheet into a degenerative model. | Mouse | 2–24 w |
| Decembrini et al., 2014 | – | mESC | Organoid model for retinal cells transplantation. | Mouse | 3 w |
| Mandai et al., 2017a | – | miPSC | Retinal tissue transplant in a degenerative model. | Mouse | 4 w |
| Johnson and Martin, 2008 | – | Rat retina h-müller cells | Organotypic culture. Transplant of cells in an ocular hypertension model. | Rat | >2 w |
| Santos-Ferreira et al., 2016a | Matrigel | mESC | Organoid model. Transplantation of photoreceptors into mouse models. | Mouse | 4–24 w |
| Santos-Ferreira et al., 2016b | Matrigel | mESC | Organoid model. Transplantation of photoreceptors into mouse models. | Mouse | 10 w |
| Singh D. et al., 2018 | Gelatin Chondroitin Sulfate Hyaluronic Acid | hESC | Biomaterials are used to develop a flat sponge retinal organoid that improves implantation and interaction with host tissue. Subretinal implant. | Mouse | 12 w |
| Julien et al., 2011 | Polyimide, gelatin | Rat retina | Subretinal implantation of organotypic layers in a biofunctionalized membrane maintaining a laminated format (Foils). | Rat | 1 w (in vitro) 9 w (in vivo) |
| McLelland et al., 2018 | – | hESC | Subretinal implantation or retinal sheets from organoids integrate in the host tissue. | Rat | 8–43 w |
| Singh et al., 2019 | – | hESC | Subretinal implantation or retinal tissue. | Cat | 4–9 w |
| Koss et al., 2016 | Parylene C | hESC | Subretinal implantation of a layer of RPE on mesh. | Yucatan minipig | 4 w |
| Xian et al., 2019 | Poly (Lactic-Co-Glycolic) (PLGA) | hiPSC | Epiretinal transplantation of retinal organoids using PLGA-composites. | Monkey | 8 w |
| Mandai et al., 2017b | – | hiPSC | Transplantation of a retinal pigment epithelial cells sheet in a AMD model. | Human | 52 w |
mESC, mouse embryonic stem cell; miPSC, mouse induced pluripotent stem cell; hESC, human embryonic stem cell; hiPSC, human induced pluripotent stem cell.