Skip to main content
. 2020 Dec 10;7:594192. doi: 10.3389/fcvm.2020.594192

Table 3.

Association of the area percentage of OM to categorical baseline characteristics.

Characteristic All patients Female Male
Yes No p Yes No p Yes No p
Previous invasive treatments for LEAD 0.192 (0.428) 0.158 (0.256) 0.670 0.301 (0.566) 0.116 (0.196) 0.136 0.119 (0.297) 0.183 (0.285) 0.057
Severity of LEAD symptoms 0.204a 0.977a 0.066a
     Claudication 0.131 (0.241) 0.155 (0.203) 0.113 (0.261)
     Rest pain 0.148 (0.155) 0.118 (0.160) 0.158 (0.156)
     Ischemic ulcer or  gangrene 0.377 (0.675) 0.609 (1.143) 0.275 (0.413)
Claudication vs. rest pain/ulcer/gangreneb 0.131 (0.241) 0.252 (0.473) 0.101 0.155 (0.203) 0.281 (0.657) 0.894 0.113 (0.261) 0.220 (0.316) 0.022
Risk factors
Smoking status (n = 88) 0.262a 0.350a 0.400a
     Never 0.028 (0.057) 0.028 (0.057) N/A
     Current smoker 0.256 (0.479) 0.278 (0.547) 0.236 (0.422)
     Ex-smoker 0.118 (0.165) 0.151 (0.185) 0.107 (0.160)
Diabetes 0.199 (0.434) 0.161 (0.293) 0.363 0.547 (0.880) 0.130 (0.193) 0.029 0.109 (0.147) 0.188 (0.360) 0.745
Dyslipidemia (n = 89) 0.182 (0.357) 0.093 (0.169) 0.341 0.216 (0.452) 0.146 (0.201) 0.882 0.163 (0.296) 0.004 (0.007) 0.150
Coronary artery disease 0.123 (0.166) 0.202 (0.410) 0.951 0.090 (0.132) 0.264 (0.502) 0.371 0.141 (0.183) 0.162 (0.339) 0.412
Cerebrovascular disease 0.155 (0.177) 0.176 (0.356) 0.778 0.199 (0.250) 0.206 (0.438) 1.000 0.122 (0.134) 0.157 (0.299) 0.648
Medications
ACE inhibitors/ATR blockers 0.179 (0.352) 0.160 (0.330) 0.286 0.246 (0.502) 0.135 (0.228) 0.530 0.146 (0.250) 0.188 (0.425) 0.433
Aspirin 0.174 (0.361) 0.173 (0.304) 0.765 0.235 (0.484) 0.128 (0.174) 0.838 0.137 (0.259) 0.200 (0.364) 0.538
Clopidogrel 0.190 (0.169) 0.172 (0.360) 0.286 0.242 (0.154) 0.196 (0.471) 0.136 0.007 (0.009) 0.160 (0.294) 0.366
Statins 0.154 (0.322) 0.219 (0.394) 0.864 0.239 (0.491) 0.129 (0.184) 0.676 0.103 (0.134) 0.276 (0.479) 0.531
Warfarin 0.077 (0.119) 0.179 (0.351) 0.929 N/A 0.206 (0.422) N/A 0.077 (0.119) 0.161 (0.299) 0.868

Note. Area percentage of OM is presented as mean (±SD). Information of each clinical parameter was available for all the patients unless otherwise stated. Association of amount of OM in a slide to categorical clinical parameters calculated by Mann–Whitney U test.

“Yes” refers to the patients having the clinical characteristic, and “No” to the patients not having the clinical characteristic.

OM osteoid metaplasia; LEAD, lower extremity artery disease.

a

Overall comparison by Kruskal–Wallis test between all the groups.

b

“Yes” for claudication and “no” for rest pain/ulcer/gangrene.