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. 2020 Dec 10;11:578069. doi: 10.3389/fimmu.2020.578069

Figure 2.

Figure 2

Complement regulators associated with pathologies. Overview of the major pathologies associated with complement regulators and polymorphisms or deficiencies associated with disease. (A) In the kidney, mutations in CFH, CFI and CD46 are associated with aHUS, C3 glomerulopathy and IgA nephropathy. (B) Polymorphisms in CLU and CR1 have been found to increase risk of AD. One of these CLU polymorphisms is also a risk factor for PD. (C) On erythrocytes, deficiencies of CD55 and CD59 on blood cells contribute to PNH, with isolated CD59-deficiency also associating with chronic hemolysis. (D) CFH, CFI and VTN, as well as a CFHR1-3 deletion have been associated with AMD. A CLU polymorphism was found in pseudoexfoliation syndrome and Fuchs’ endothelial dystrophy. Lastly, a CD55 polymorphism is a risk factor for pathological myopia. Figure designed using Servier Medical Art.