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. 2020 Dec 23;10:22375. doi: 10.1038/s41598-020-78758-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The scatter plot shows the mutated AP score (Y-axis) against its wildtype AP score (X-axis) for each peptide variant. Each data point (blue circles) represents a peptide variant identified in a SARS-COV-2 sequence when comared to the Genbank (Wuhan) reference sequence. There was a total of 1122 peptide variants identified in such a comparison and illustrated on the plot. The orange line is a least square fit with slope = 0.72. Peptide variants on the green dashed line of slope 1 would show no change in AP after introduction of the peptide variant.