Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 23;10:22375. doi: 10.1038/s41598-020-78758-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The plot illustrates a set of digital twin simulation experiments to identify effective epitope hotspots based on immune presentation (IP) and antigen presentation (AP), which broadly cover the population. The aim of the analysis was to select an optimum set of hotspots (respecting a given budget) such that the likelihood that each citizen (in a given modelled population) has a positive response is maximized (or, equivalently, that the log likelihood of no response for each citizen is minimized). Ten simulations were run for each region illustrated, where each simulation consisted of 10,000 digital twins (see supplementary file for more details). This plot shows the number of times each hotspot was selected for use in one of the simulations. Each hotspot selected at least 10 times is shown on the x-axis, and the y-axis shows the selected counts per region. Each bar corresponds to a different region-specific simulation setting. A subset of 5 hotspots were selected based on their profile across the AP and IP digital twin analyses, which could theoretically provide coverage of > 90% across a global population (highlighted in yellow).