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. 2020 Dec 10;8:596788. doi: 10.3389/fcell.2020.596788

FIGURE 7.

FIGURE 7

The anti-tumor effect of DHA and cisplatin on TE-1-derived xenografts in mice. (A) The effect of administration of DHA alone, cisplatin (CDDP) alone or the DHA/CDDP combination on the tumor volumes. Tumor volumes are expressed as mean ± SD (n = 4 per group). (B) The average body weight of each group is expressed as mean ± SD (n = 4 per group). (C) The expression levels of nuclear Gli1, PTCH1, and Sox2 were detected by western blot. Proteins were extracted from the tumor tissues of mice in the four groups. The expression levels of nuclear Gli1, PTCH1, and Sox2 were detected by western blot. Proteins were extracted from the tumor tissues of mice in the four groups. (D) Schematic of the mechanism by which Shh pathway activation results in cisplatin resistance in ESCCs and reversing resistance by novel Shh pathway inhibitor DHA. All error bars are s.e.m. ∗P < 0.05 for DHA alone, CDDP alone or the combination treatment compared with the vehicle control. #P < 0.05 for the combination treatment compared with single administration of DHA and CDDP.