Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 10;8:597857. doi: 10.3389/fcell.2020.597857

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Delbaere, De Clercq, Mizumoto, Noborn, Bek, Alluyn, Gistelinck, Syx, Salmon, Coucke, Larson, Yamada, Willaert and Malfait.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

μCT analysis of adult WT and b3galt6^–/– zebrafish. Quantitative μCT analysis of the vertebral column in five mutants vs. five WT zebrafish at the age of 4 months. The bone volume, tissue mineral density (TMD) and bone thickness were calculated for three parts of each vertebra: the vertebral centrum, the neural associated element (neural arch and neural spine) and the haemal associated element (haemal arch and haemal spine). Plots associated with a significant difference are colored in a lighter coloring scheme. The X-axis represents each vertebra along the anterior-posterior axis. The volume is significantly reduced for each part of the vertebra in b3galt6^–/– zebrafish (P < 0.01, P < 0.001, and P < 0.000001, respectively). The thickness of the haemal (P < 0.01) and neural (P = 0.001) associated element is also significantly reduced in the mutants whereas the centrum thickness is not significantly reduced in b3galt6^–/– zebrafish (P = 0.12). TMD is not significantly different between b3galt6^–/– zebrafish and WT siblings when not normalized for standard length (P > 0.2). Data are presented as mean ± SEM. TMD, tissue mineral density; HA, hydroxyapatite.